Thru-hiking backpacks commonly sit in the 50–65L range (ULA says its 68L Circuit has been the most popular Pacific Crest Trail pack), which is smaller than many hikers expect given trail lengths that can run 2,000-plus miles. The reason is resupply frequency: thru-hikers restock food every three to five days at a trail town, post office or resupply point, so the pack is never carrying more than a short segment's worth of food regardless of how long the overall trail is.

What does drive capacity on a thru-hike is a combination of base gear bulk and the longest stretch between resupply points — some sections of long trails run six or more days without a town, which pushes toward the higher end of the 50–65L range. Ultralight thru-hikers running a low base weight can comfortably fit a standard resupply segment into 40–50L, while hikers carrying bulkier three-season gear tend toward 55–65L.

Durability matters as much as capacity for a thru-hike pack, since the fabric and stitching need to survive months of daily use rather than a handful of weekend trips. Many thru-hikers choose packs built with tougher fabrics or reinforced high-wear zones — hipbelt attachment points, the bottom panel, and zipper pulls — over an equally sized pack optimized purely for minimum weight, since a failure hundreds of miles from a gear shop is a bigger problem than carrying a few extra ounces.

Weight loss over the course of a long trail is another factor some thru-hikers plan around: food consumption drops base weight day to day, and many hikers also swap gear or mail home unnecessary items partway through, which can make a pack that felt right-sized at the trailhead feel slightly large by the final weeks.